My partner has had idiopathic hypersomnia (sleeps 12 hours most days, as much as 18 hours some days) for a few years now, and so far nothing we’ve tried has worked without awful side effects (e.g. constant heart palpitations and panic attacks.)
I had been looking into orexin agonists (along with other things like H3 autoreceptor antagonists) back when they were just a concept. It’s good to see them finally reaching commercialization. Although they’re not approved by our own (Canadian) regulatory body quite yet.
Now that they’re approved in the US, though, I’m looking very much forward to seeing how these drugs perform in off-label-ish treatment of the various other sleep disorders that I’m sure clinicians will now begin throwing them at.
kbrannigan 52 minutes ago [-]
To get a job at our company take three pills of brainOzempic every day to maximize productivity.
We have our NeuroLinkBrain Implant plugin to AI agent , so that you can vibe code 24/7 . To maximize shareholder value.
anakaine 9 minutes ago [-]
I reckon I'll buy some landscaping machinery and a truck before I ever sign up for that distopian nightmare. At least sound ordinance would prevent 24/7 operation.
seeknotfind 8 minutes ago [-]
Is this supposed to be scary or amazing?
fedpost 9 minutes ago [-]
Well, they're filming the next season of black mirror right now, it's probably not too late to throw this one in there.
SoupBread 50 minutes ago [-]
It sounds like is a genuine treatment for those who suffer from narcolepsy, and everything else is merely speculative and has seem pretty bad side-effects.
bitexploder 37 minutes ago [-]
There is evidence that some forms of ADHD are effectively just the brain falling asleep rapidly and then waking up. This form cam be attenuated with norepinephrine reuptake inhibitor alone. Presents with ADHD like symptoms. But it’s a new thing most likely. Called “Cognitive Disengagement Syndrome”.
If this means I don't have to take Methylphenidate to function 100% all the time and as a result feel tremendously anxious 100% all the time. SIGN ME UP.
didgeoridoo 32 minutes ago [-]
Adding guanfacine (Intuniv) to my methylphenidate took the weird anxious-angry edge off. Would be nice to not have to take one med to fix the side effects of the other, though.
fennec-posix 15 minutes ago [-]
Interesting, will check it out. Cheers!
genghisjahn 11 minutes ago [-]
My son takes the methylphenidate / guanfacine combo as well and it’s been a game changer.
hirvi74 9 minutes ago [-]
Any other benefits?
SV_BubbleTime 33 minutes ago [-]
You sure about that math?
fennec-posix 15 minutes ago [-]
I'm honestly not sure about anything man
fishfasell 46 minutes ago [-]
Despite the stigma surrounding semaglutide, its impact across various health conditions has been remarkable. Bringing that same level of innovation to cognitive disorders could be truly transformative for society
> IMO the much more likely explanation is that the brain uses contrastive learning somewhere. [...] Instead of using calculus and outer products to calculate derivatives, you feed real data and false data forward through the network and each neuron tracks and trains on the difference.
Kinrany 26 minutes ago [-]
Separately, do I understand the idea correctly:
- when learning on the real examples, just propagate forward
- when learning on the fake examples, first generate them by propagating white noise backward
inigyou 4 minutes ago [-]
That's a technique that was tried in machine learning and worked (although obviously not optimally or we'd all be using it by now).
Kinrany 28 minutes ago [-]
I'm curious if there is an explanation for it not being more common to sleep like dolphins do, small parts of the brain at a time.
almost_usual 57 minutes ago [-]
Sleep less and sit more. What a species we’ve become.
50 minutes ago [-]
madhacker 40 minutes ago [-]
"Others are exploring their use for treating sleep apnoea, which is a far more common disorder." CPAP biomedical equipment manufacturer watch out!
copperx 2 hours ago [-]
A better modafinil? Sign me up.
livinglist 48 minutes ago [-]
24/7 stock market, least sleep needed, most AI piled, I’m very excited!
inigyou 2 minutes ago [-]
Cryptocurrency markets are open 24/7 btw.
Everyone involved in a stock market agrees it's quite useful to have a separation between days, although you could have a 23.5/7 stock market with only half hour day-ends. That's when things like index rebalancing, addition, removal, stock splits occur. You say whoever holds stock X at end of a certain day holds stock Y+Z at the start of the next day (due to a company splitting up) and there's no need to argue about a certain millisecond because you either had it at closing time or you didn't.
EA-3167 1 hours ago [-]
The second I read the print in Nature a bit ago I knew some version would show up here. I swear I’ve met deployed Marines less obsessed with staying awake through chemistry than some people here.
ValdikSS 1 hours ago [-]
Hooray fatal insomnia
steele 1 hours ago [-]
Vegetable diarrhea, hypothyroidism medication defect causes hyperthyroidism, overseas underground labs are preparing for US govt promoted SARM goblin hordes, and the US Armed Services want to measure the gonads of 17yo recruits. Imma sit this one out.
acosmism 1 hours ago [-]
wow. now i'm really excited for the future
Rendered at 03:10:02 GMT+0000 (Coordinated Universal Time) with Vercel.
I had been looking into orexin agonists (along with other things like H3 autoreceptor antagonists) back when they were just a concept. It’s good to see them finally reaching commercialization. Although they’re not approved by our own (Canadian) regulatory body quite yet.
Now that they’re approved in the US, though, I’m looking very much forward to seeing how these drugs perform in off-label-ish treatment of the various other sleep disorders that I’m sure clinicians will now begin throwing them at.
We have our NeuroLinkBrain Implant plugin to AI agent , so that you can vibe code 24/7 . To maximize shareholder value.
> IMO the much more likely explanation is that the brain uses contrastive learning somewhere. [...] Instead of using calculus and outer products to calculate derivatives, you feed real data and false data forward through the network and each neuron tracks and trains on the difference.
- when learning on the real examples, just propagate forward
- when learning on the fake examples, first generate them by propagating white noise backward
Everyone involved in a stock market agrees it's quite useful to have a separation between days, although you could have a 23.5/7 stock market with only half hour day-ends. That's when things like index rebalancing, addition, removal, stock splits occur. You say whoever holds stock X at end of a certain day holds stock Y+Z at the start of the next day (due to a company splitting up) and there's no need to argue about a certain millisecond because you either had it at closing time or you didn't.