NUMA can cause really crappy performance. We deployed a Go based LLM gateway in Kubernetes deployed on a server with hundreds of CPU cores. We didn't explicitly set GOMAXPROCS so Go runtime scheduled goroutines over different CPUs and it constantly used 200% CPU and GC was causing latency spikes. Then we set GOMAXPROCS 8 and all performance issues went away. Until recently Kubernetes didn't work well with NUMA.
Scaling to large core counts has a lot of gotchas.